Excellent little pistol, I bought one back in November. We've put close to 1000 rounds through it, and the only feeding or jamming issues were due to a box of CCI Stingers that had too much wax on them from the factory. I use either the CCI Stingers, or remington thunderbolts in mine.
With the smallish frame, light weight, and light recoil, this has been the weapon of choice for friends to shoot a pistol for the first time.
As far as for home defense or concealed carry, I've always believed in the adage "the best gun for defense is the one you have." Meaning, any is better than nothing. and train with what you have. While I would prefer she reach for one of the 9mms we have first, the fact that she can dump all ten rounds in the space of a grapefruit just as quick as she can pull the trigger makes me comfortable that she can protect herself with the P22.